Consistent with broad polygenic modelling assumptions, we observed a general propensity for SNPs that increase risk for AD (odds ratio (OR) > 1) to associate with reduced whole GM CBF, while alleles that conferred relative protection (OR < 1) for AD where associated with an increase in whole GM CBF (Fig. 2; sign test for direction of effects: p = 0.041). This evidence concerns the gene CEBPZ and Alzheimer disease.