OCA2 and Lambert-Eaton myasthenic syndrome: P/Q-type voltage-gated calcium channel (P/Q-VGCC) antibodies are prevalent in about 40%of patients with PCD with small-cell lung cancer.13,14 The antibodies arecommonly associated with Lambert-Eaton myasthenic syndrome (LEMS) and may additionallypresent with PCD (with or without LEMS), possibly due to the recognition of varyingtarget epitopes.3,13,15 At theneuromuscular junction, P/Q-VGCC antibodies were shown to cause a downregulation andblocking of Cav 2.1 receptors.16,17 In PCD withanti–P/Q-VGCC antibodies, the pathogenic mechanisms are unclear.