A role for myeloid cell–expressed Gpx4 in host resistance to infection and cancer has been documented in many previous studies involving different mechanisms and outcomes (Amaral and Namasivayam, 2021; Canli et al., 2017; He et al., 2022; Kang et al., 2018; Zhu et al., 2019). The gene discussed is GPX4; the disease is cancer.