Since Gpx4 function depends on selenium, one approach would be to provide this micronutrient as a dietary supplement, a general strategy, which in one study involving co-administration with vitamin E was shown to reduce the oxidative stress response while potentiating antioxidant status in patients with pulmonary tuberculosis (Seyedrezazadeh et al., 2008). Here, GPX4 is linked to pulmonary tuberculosis.