KRAS and adenoma: Pathological analysis performed as above in the lung revealed that the G12D mutation consistently induced more AAH and/or adenomas than the Q61R mutation when Kras was encoded with either common or native rare codons, both in terms of the number of animals with these lesions and the total number of these lesions per animal (Figure 4B and F, Figure 4—figure supplements 5; 6A, and Supplementary file 5).