Comparing the G12D versus Q61R transcriptomes revealed both G12D-mutant alleles induced the Estrogen Response Late hallmark while the Q61R-mutant alleles induced DNA Repair and P53 Pathway and decreased Interferon Alpha Response hallmarks, suggesting that there is a strong tumor-suppressive response uniquely activated by the Q61R-mutant alleles (Figure 3C, Figure 3—figure supplement 1C, Figure 3—source data 2). Here, TP53 is linked to neoplasm.