Specifically, IL-1β and IL-6 expression was significantly increased at 1 dpi, and IL-6 sustained the high expression level up to 3 dpi, which suggests that IL-1β plays a crucial role in the response to infection by Zika virus [23] as well as other flaviviruses, WNV [24] and JEV [25]. The gene discussed is IL6; the disease is infection.