In univariate analysis (Table 2), the likelihood of OM among patients who underwent CPM increased with age (p = 0.008), a known non‐BRCA high‐penetrance pathogenic variant (p = 0.001), ADH within the prophylactic breast (p = 0.046), and the presence of LCIS in either the prophylactic or therapeutic mastectomy specimen (p = 0.006). The gene discussed is AVP; the disease is ocular melanoma.