Among GBM, the proportion with a CD4 <350 cells/mm3 fell from 36% in 2011 to 30% in 2014, rising to 41% in 2019, compared with a relatively steady reduction among heterosexual men (from 68% in 2011 to 59% in 2019) and women (from 58% in 2011 to 51% in 2019). The gene discussed is CD4; the disease is glioblastoma.