TNFRSF12A and early-onset autosomal dominant Alzheimer disease: We find that this cleavage occurs within the transmembrane domain of Fn14 and is mediated by the intramembrane protease γ‐secretase, which has key roles in development through cleavage of the Notch receptor and in Alzheimer's disease, where it contributes to generation of the pathogenic amyloid β (Aβ) peptide (De Strooper et al, 1998, 1999; Wolfe et al, 1999; Güner & Lichtenthaler, 2020).