To test whether γ‐secretase also controls downstream signaling of Fn14, we used the ovarian cancer SKOV‐3 cell line, which secretes TNF as a result of TWEAK‐stimulated Fn14 signaling in an NFκB‐dependent manner (Vince et al, 2008). The gene discussed is TNFRSF12A; the disease is ovarian carcinoma.