However, increased Fn14 levels or signaling are also linked to chronic diseases, such as most solid tumor types, acute kidney disease, fibrosis, Alzheimer's disease, and cerebral ischemia (Cheng et al, 2013; Perez et al, 2016; Hu et al, 2017; Wang et al, 2017; Connolly et al, 2021; Nagy et al, 2021). Here, TNFRSF12A is linked to Alzheimer disease.