Interestingly, the splenic Tph cell level correlated with splenomegaly more significantly than Tfh cells (Fig 2D) and a similar finding for Tph correlation with serum levels of ANA and IgG2a, but IgG1 and IgG2b had no correlation with either cell subset (Fig EV2C and D). Here, TPH1 is linked to Splenomegaly.