TNFSF10 and cancer: Two major apoptosis pathways are necessary for regulating cell death in cancers: the intrinsic pathway, involving perforin and granzyme B (Voskoboinik et al., 2006), and the extrinsic pathway, involving FasL and TRAIL (Leite-de-Moraes et al., 2000; Ferguson & Griffith, 2007).