Pre‐incubation of ML141 with EV‐HT29 or EV‐MC38 significantly inhibited the upregulation of p‐RIP2, p‐p65 and p‐p38 expression as well as the increase in IL‐6 mRNA expression in THP‐1 cells (Figure 3f,g), suggesting that inhibition of CDC42 in CRC‐EVs attenuated NOD1 activation. This evidence concerns the gene CDC42 and colorectal carcinoma.