CRC‐EVs were engulfed by macrophages (data not shown) and EV‐mediated production of proinflammatory cytokines and chemokines, such as IL‐6, CCL1 and CCL2, was dependent on NOD1, as confirmed by treatment with the selective NOD1 antagonist (ML130) and NOD1 knockout in macrophages. Here, IL6 is linked to colorectal carcinoma.