Previous studies have shown that multiple PRRs (TLR2, TLR3, TLR4, TLR7, TLR8 and RIG‐1) in stromal cells recognise tumour cell‐derived EVs and participate in tumour metastasis (Chalmin et al., 2010; Fabbri et al., 2012; Forte et al., 2012; Liu et al., 2016, 2010; Zhou et al., 2020). Here, TLR4 is linked to neoplasm.