In summary, high CDC42 cargo levels in CRC‐EVs were delivered into macrophages, where they switched to a GTP‐bound active state to activate NOD1, with consequent RIP2 phosphorylation, triggering downstream NF‐κB and p38‐MAPK‐dependent inflammatory cytokine and chemokine (i.e., IL‐6, CCL1 and CCL2) release, which promoted CRC metastasis (Figure 7). Here, NOD1 is linked to colorectal carcinoma.