Given that tumour cell‐derived EV‐activated PRRs induce inflammatory responses to promote metastasis (Zhou et al., 2020) and NOD1 activation has been implicated in CRC metastasis (Jiang et al., 2020), we next explored whether CRC‐EV‐mediated NOD1 activation could promote CRC cell growth and migration. The gene discussed is NOD1; the disease is colorectal carcinoma.