Multivariate analysis showed that young age (< 40 years; odds ratio [OR], 6.307 [95% confidence interval (CI), 1.114–34.908]; P = 0.035), organ bleeding (OR, 13.672 [95% CI, 2.437–76.689]; P = 0.003), and ANA positivity (1:160; OR, 6.638 [95% CI, 1.399–31.504]; P = 0.017) were significantly associated with the development of SLE. Here, BTG3 is linked to systemic lupus erythematosus.