In cell and animal experiments, it was confirmed that overexpression of hsa_circ_7042 could inhibit the gene expression level of miR-369-3p, upregulate the expression levels of CDH2 and BMP2, activate the PI3K/Akt pathway, and enhance the resistance effect of NP cells to IDD. This evidence concerns the gene BMP2 and intervertebral disk degenerative disorder.