ASXL1 and acute myeloid leukemia: OGT was found to stabilize ASXL1 via GlcNAcylation, and knockdown of ASXL1, OGT, HCF1, or MLL5 blocked ATRA-induced myeloid differentiation and decreased H3K4 methylation, altering the expression of genes involved in myeloid differentiation, ribosomes/translation, and mRNA splicing/spliceosomes in HL-60 cells (AML cell line) [123].