Homozygous or hematopoietic-specific loss of Asxl1 results in the abnormal self-renewal capacity of HSCs and the development of MDS or MDS/MPN-like disease [70, 71], with HSC/HPCs from the latter exhibiting decreased global levels of H3K27me3 and the increased expression of posterior Hoxa genes [70]. Here, ASXL1 is linked to myelodysplastic syndrome.