ASXL1 and neoplasm: Studies exploring the effects of ASXL1 or ASXL2 loss demonstrated their critical role in hematopoiesis and tumor suppression via their regulation of PcG and TrxG complex activities, which antagonistically regulate the expression of genes involved in hematopoietic stem cell (HSC) self-renewal, proliferation, and differentiation into hematopoietic progenitor cells (HPCs).