HSC/HPCs from Asxl1−/− mice exhibited increased apoptosis and mitosis, similar to human MDS, and the increased expression of Hoxa genes (Hoxa5/7/9/10), abnormal expression of genes regulating apoptosis (e.g., Bcl2 downregulated), as well as reduced global levels of H3K27me3 and H3K4me3 [71]. This evidence concerns the gene ASXL1 and myelodysplastic syndrome.