ASXL1 and acute leukemia: Sublethally irradiated mice transplanted with bone marrow cells harboring an Asxl1 mutation derived from the most common ASXL1 mutation (G646WfsX12) demonstrated multilineage myeloid dysplasia, occasional progression to acute leukemia, and markedly decreased H3K27me3 levels around the promoter regions of Hoxa genes in the bone marrow cells from the mice developing MDS [55].