Another heterozygous Asxl1 mutation knock-in mouse model (Asxl1G643fs/+) recapitulated human MDS and MDS/MPN-like disease after a long latency; decreased H2AK119Ub1 deposition in HSCs due to mutant Asxl1 resulted in the leukemogenic derepression of senescence-associated genes [72]. This evidence concerns the gene ASXL1 and myelodysplastic syndrome.