ASXL2 and myeloid leukemia: Micol et al. corroborated these findings demonstrating by ChIP-seq analysis that ASXL2 loss (following RNAi-mediated ASXL2 depletion in the myeloid leukemia cell line SKNO-1) was associated with increases in signals for H3K27ac and/or H3K4me1 at enhancers (active/poised) [61].