While both JAK2V617F with WT Asxl1 and JAK2V617F;Asxl1+/− mice developed MPN (i.e., PV, ET, and MF), MPN occurred sooner in the latter with more progressing to myelofibrosis and secondary AML (sAML) [69]. The gene discussed is ASXL1; the disease is myelofibrosis.