STUB1 and myeloid neoplasm: CHIP portends an increased risk of developing a hematologic malignancy [14] and underscores the concept that myeloid malignancies develop initially from a pre-leukemic stem cell that accumulates additional genetic alterations to become a malignant/leukemic stem cell with dysregulated self-renewal, enhanced proliferation, and impaired ability to differentiate into HPCs [15].