While hematopoietic-restricted BAP1 loss in mice has been reported to lead to myeloproliferative [103] or MDS-like disease [104], somatic BAP1 mutations, unlike in some solid tumors (e.g., malignant mesothelioma and melanoma), are rarely present in myeloid malignancies [105]. Here, BAP1 is linked to malignant mesothelioma.