Although more could arise with future studies, potential targets could be TRPV4 [28], the LPA signalling pathways [15], the NKCC1 [6], or the regulatory kinases, SPAK [69, 70] and the serum/glucocorticoid-regulated kinase 1 (SGK1) [71] inhibition of which may reduce hydrocephalus or lesion size in different cerebral pathological insults. Here, SGK1 is linked to Hydrocephalus.