IL4 and cancer: In the tumoral context, hypothermia provides an immunosuppressive, hence, pro-tumoral microenvironmental due to impaired CD8+ T cell function, an increase of the regulatory and Th2 cells, and higher levels of the cytokines IL-4 and IL-10, which increase cancer progression and metastasis [114–116].On the other hand, hyperthermia is recognized to elicit a more robust immune response against infection, injury, and cancer [117].