CD4 and Plasmodium falciparum malaria: In accordance with previous reports from the same study area [23], loss of circulating CD4+ T cells in uncomplicated vivax and severe falciparum malaria relative to controls was observed (Table 1) but this was not correlated with changes in PMN-MDSC in either patient group (rs = 0.21, p = 0.66 and rs = 0.20, p = 0.48, respectively).