Considering the possible interaction between LMNA and BICD2 and the heart failure symptoms of BICD2 mutant patients, we hypothesized that the homozygous variant (NM_001003800.1:c.2429G > A) in the C-terminal region of BICD2 (Fig. 1C) would be a candidate DCM-causative variant in this family. This evidence concerns the gene BICD2 and heart failure.