The genes differentially expressed after HDIR (N2+ /N1 vs. N0 and N1 vs. N0) were associated to regulation of apoptosis [TNFRSF10A, (Pan et al. 1997)], survival in chronic lymphocytic leukemia [COBLL1, (Plešingerová et al. 2018; Plesingerova et al. 2017)], prevention of accumulation of reactive oxygen species [SESN2, (Wang, et al. 2019)], cell growth/proliferation, heat shock response, and tumorigenesis [EEF1A1 (also known as METTL13), which is methylated by EEF1AKNMT (Vera et al. 2014; Liu et al. 2019)]. Here, COBLL1 is linked to B-cell chronic lymphocytic leukemia.