IL17F and juvenile idiopathic arthritis: Our study showed a significantly higher risk to develop high activity JIA in individuals with AG genotype of Interleukin-17F 7383A/G polymorphism compared to AA subjects (p = 0.009), whereas no significant association was found between genotype distributions of Interleukin-17F 7488A/G polymorphism and JIA activity (p = 0.95).