IL17F and rheumatoid arthritis: In addition, individuals with the IL17F 7488A/G genotype were found to be at an increased risk of developing RA at the HDA level compared to healthy controls (OR = 2.83, 95% CI = 1.11–6.9, p = 0.02).36 Similarly, Demircan et al., determined that there was no association between polymorphisms of the IL-17F gene and susceptibility to RA patients.