NAT10 and cancer: Remarkably, the prognostic and immunological role of NAT10 has been observed in most cancers, such as hepatocellular carcinoma14, gastric cancer15, and leukemia16; either by enhancing cancer cell proliferation, facilitating cancer metastasis or altering metabolism et al. Interestingly, NAT10 genetic depletion or its chemical inhibition by the compound Remodelin has been reported to enhance healthspan in aging mouse model17.