This examination showed that in dementia patients with amyloidosis, an expanded degree of blood pro-inflammatory cytokines (IL-6, CXCL2, NLRP3, and IL-1β) was positively correlated with a number of some pro-inflammatory gut bacteria such as Escherichia/Shigella and negatively associated with anti-inflammatory E.rectale taxon. This evidence concerns the gene NLRP3 and amyloidosis.