High levels of CD68+ and CD163+ macrophages were identified in IPN, with a median of 100 total and 80 stromal CD68+ cells per TMA dot and the ratio of CD163+ to CD68+ was 0.88 in the total and 1 in the stromal compartment (Fig. 2f, g). This evidence concerns the gene CD163 and bile duct papillary neoplasm.