In addition, we previously characterised the immune infiltrates in non-IPNB/ITPN BTC, thereby revealing a significantly longer overall survival in patients with high intraepithelial CD4+, CD8+ or FOXP3+ T lymphocytes densities, particularly in extrahepatic CCA and GBC but not in intrahepatic CCA [26, 27]. This evidence concerns the gene CD8A and cholangiocarcinoma.