By analyzing the transcriptional expression of peripheral blood caspase-1 and associated inflammasomes in patients with acute brucellosis, Karaca et al. found that in acute brucellosis, caspase-1 and associated inflammasomes are activated, thereby inducing the secretion of cytokines, such as IFN-γ and IL-18, which continue to induce a cellular immune response30. The gene discussed is IFNG; the disease is brucellosis.