The present study aims to investigate the expression levels of inflammasomes, such as AIM2 and NLR family PYD-domain-containing 3 (NLRP3), in peripheral blood samples from patients with acute or chronic brucellosis and the levels of inflammatory cytokines (such as IL-1β, IL-18, and IFN-γ) in the systemic circulation. This evidence concerns the gene IL18 and brucellosis.