In summary, the mRNA expression analyses are consistent with the enhanced cytotoxic T-cell and DC activation observed by flow cytometry (Fig. 1, Supplementary Fig. 4) and demonstrate that the superior anti-tumor immune response observed upon combined PARP inhibition and STING agonism is a result of enhanced interferon signaling, antigen processing, and leukocyte and DC functions. The gene discussed is STING1; the disease is neoplasm.