For example, abnormal startle reflex and behavior as well as abnormal anxiety-related response were shared by EMX2, MAGI2, GABRG2, GRM3, KCNJ3, and KCNH5. We observed hyperactivity/hypoactivity and impaired motor capabilities as relatively consistent behavioral patterns among these knockout mice while abnormal neuron physiology was shared predominantly as a common phenotype in the nervous system. The gene discussed is KCNH5; the disease is Anxiety.