PIEZO1 and myocardial infarction: After identifying a relationship between tissue stiffening and upregulation of Piezo1 and integrin β1 in a rat model of myocardial infarction (MI), we used integrated in vitro hydrogel culture and in silico mathematical models to explore the potential for a mechanical PFL between Piezo1 and integrin β1 in stiffness-induced CF phenotypic transition.