We used flow cytometry to confirm the increase in the number of tumor infiltrating stem-like T cells (Fig. 4d) and elevated expression of the TCF-1 protein in the total population of tumor infiltrating CD8+ T cells (Fig. 4 e, f, histograms and controls are shown in Supplementary Fig. 6a) in response to lactate treatment. Here, TCF7 is linked to neoplasm.