This revealed 11 samples across six different cancer types with a nonsynonymous mutation in a neddylation-associated gene: four with a UBE2M mutation, five with a NAE1 mutation, one with a NEDD8 mutation, and one with a mutation in the NEDD8-binding domain of CUL3 (Supplementary Figs. 1 and 4c). The gene discussed is CUL3; the disease is cancer.