Indeed, 80–90% of leiomyomas harbor one of three genetic changes: a hotspot mutation in mediator complex subunit 12 (MED12), a chromosomal aberration resulting in upregulation of high mobility group AT-hook 2 (HMGA2), or biallelic loss of fumarate hydratase (FH) [4]. The gene discussed is HMGA2; the disease is leiomyoma.