Pathway enrichment analysis confirmed significant dysregulation of the NRF2 pathway in this novel leiomyoma subtype (q-value = 3.29 × 10−03; Supplementary Table 5), including upregulation of the well-established NRF2 target gene NQO1 (FC = 5.58, q-value = 3.07 × 10−12). The gene discussed is NFE2L2; the disease is leiomyoma.