Leiomyomas of the FH subtype are characterized by activation of nuclear factor, erythroid 2 like 2 (NRF2) target genes, including upregulation of aldo-keto reductase family 1 member B10 (AKR1B10) and NAD(P)H quinone dehydrogenase 1 (NQO1) [9, 10]. The gene discussed is NFE2L2; the disease is leiomyoma.