This suggests that morphological features typically seen in FH-deficient tumors may be related to activation of the NRF2 pathway itself, and not with loss of FH. The majority of AKR1B10hi leiomyomas also showed perivascular hypercellularity, a feature not typically seen in uterine leiomyomas. The gene discussed is NFE2L2; the disease is Uterine leiomyoma.