Further, miR-16 can downregulate the expression of NF-κB, NLRP3, and other inflammatory factors by targeting TLR4, thereby attenuating the inflammation in a LPS-induced acute lung injury model (20), and sepsis mice treated with miR-146a presented with decreased NF-κB activation as well as splenocyte apoptosis (29). Here, TLR4 is linked to Sepsis.