AKT1 and heart failure: Oxidative stress plays a vital role in disorders related to vascular structure and function.15 Dysfunction of cardiac mitochondria, a hallmark of heart failure and a major cause of oxidative stress, damages cellular components and thus forms a vicious circle.16 This study was designed to determine whether vaspin could alleviate cardiac remodeling through inhibiting PI3K/Akt pathway to relieve oxidative stress.