TRIM25 and infection: Overexpression of TRIM25-WT (Fig 7A, solid light blue line) dramatically represses SINV replication by 7–15 fold at earlier timepoints (6–12 hours post infection (h.p.i.)) to 43–52 fold at later timepoints (24–40 h.p.i.)compared to TRIM25 KO 293T cell lines (Fig 7A, dotted lines).