Multi-algorithmic topological analysis revealed four overlapping mammalian MRP hub genes, MRPS26, MRPS17, MRPL18, and MRPL51, with opposing tissue expression between musculoskeletal ageing and NSCLC when tissues from both groups were compared to their corresponding control states [i.e., a) older healthy vs younger healthy and b) NSCLC vs age-matched healthy]. This evidence concerns the gene MRPS17 and non-small cell lung carcinoma.