Multi-algorithmic topological analysis revealed four overlapping mammalian MRP hub genes, MRPS26, MRPS17, MRPL18, and MRPL51, with opposing tissue expression between musculoskeletal ageing and NSCLC when tissues from both groups were compared to their corresponding control states [i.e., a) older healthy vs younger healthy and b) NSCLC vs age-matched healthy]. Here, MRPL51 is linked to non-small cell lung carcinoma.