Patients SP-FFB/2020 and SP-MJMS/2020 had CD4+ T cell count of 691 cells/mm3 and 752 cells/mm3 with HIV viral loads of 290, 976 copies/mL (5.46 log) and below the limit of detection (<50 copies/mL); both with diagnoses of syphilis without any AIDS-defining disease. This evidence concerns the gene CD4 and syphilis.