Since IL-17 is a known marker of lung inflammation and asthma severity [4, 27], these data could imply the importance of expanding lung levels of LAG3+ Treg in asthmatic lung as the levels of LAG3+cTreg or LAG3+uTreg on the inflamed lung tissues were both correlated with lower serum level of IL-17. This evidence concerns the gene LAG3 and asthma.