In module 1, there were 33 nodes and 378 edges (Fig 7a), which were associated with the lymphangiogenesis pathway, including the KEGG pathways mmu04151: PI3K–Akt signaling pathway, mmu04510: Focal adhesion, and mmu05323: Rheumatoid arthritis. This evidence concerns the gene AKT1 and rheumatoid arthritis.