Compared with saline+vehicle, the lipid+vehicle infusion significantly impaired several parameters of glucose metabolism, including increasing fasting plasma glucose (FPG; 7%) and fasting plasma insulin (FPI; 22%) concentrations and the homeostatic model assessment of insulin resistance (HOMA-IR) index (26%), and reducing peripheral insulin sensitivity (M value; 14%) (Figure 3). Here, INS is linked to Insulin resistance.