Therefore, to further characterize SSc fibroblasts, we assessed coexpression of Thy-1 with FAP (Figure 1A and Supplemental Figure 1 for higher magnification) and observed a remarkable change to FAP+Thy-1+ cells in SSc (45.3% ± 6.9% Thy-1+ double-positive cells, compared with 1.4% ± 1.1% in controls) but did not note substantial differences in double-positive cells in early versus late SSc. This evidence concerns the gene THY1 and systemic sclerosis.