THY1 and fibrosis: Unsupervised pathway analysis of WT bleomycin-treated mice showed overexpression of pathways consistent with fibrosis (i.e., focal adhesion) and inflammation (leukocyte transendothelial migration and TLR signaling) with downregulation of pathways related to skin cell homeostasis (cell cycle, basal cell carcinoma, and melanogenesis) (Figure 6C), while Thy-1–KO mice treated with bleomycin differentially expressed metabolic pathways (upregulation of calcium and phosphatidylinositol signaling, downregulation of urea cycle, glycoxylate, and terpenoid metabolism) (Figure 6D).