Based on a summation of the evidence, in the normal situation of untreated progressive breast cancers, the neutrophil population undergoes mobilization and a shift in the balance toward greater N2 numbers, including the TANS that become positive for surface expression of the immunosuppressive marker PD-L1 and production of TGFβ, enabling the N2 neutrophil infiltration into tumors, resident in the more advanced stages of cancers, including metastatic tumors. The gene discussed is CD274; the disease is breast carcinoma.