Based on a summation of the evidence, in the normal situation of untreated progressive breast cancers, the neutrophil population undergoes mobilization and a shift in the balance toward greater N2 numbers, including the TANS that become positive for surface expression of the immunosuppressive marker PD-L1 and production of TGFβ, enabling the N2 neutrophil infiltration into tumors, resident in the more advanced stages of cancers, including metastatic tumors. This evidence concerns the gene CD274 and metastatic neoplasm.