A recent imaging study across presymptomatic and symptomatic carriers found distinct atrophy patterns associated with specific MAPT variants, i.e. a temporal pattern including mesiotemporal structures associated with IVS10 + 16 and R406W variants, and a frontotemporal pattern including (lateral) temporal and ventromedial regions associated with the P301L variant [84, 85]. Here, MAPT is linked to Atrophy.