CR1 and Alzheimer disease: In stage 3, two well-known AD loci showed additional genome-wide significant associations (Fig. 1, Table 2) with Aβ42 in chromosomal region 1q32.2 (Z = − 6.01; P = 1.84 × 10–9, CR1; Fig. 1a), and with pTau for the region 2q14.3 (Z = 6.15; P = 7.88 × 10–10, BIN1; Fig. 1b).