The third novel locus in this study is the region on genomic location 16q24.2 for pTau, of which the strongest associated variants are located within intronic regions of C16orf95. This locus has not been linked to (p)Tau pathology or AD in previous research, though it associated to lateral ventricular volume in the CHARGE study, including 23.5 k healthy individuals [65]. Here, C16orf95 is linked to Alzheimer disease.