CTSH and dementia: A pathway enrichment analysis of the genes associated with the variants showed 29 GO terms enriched and ‘amyloid’ is the common denominator in the names of these terms, of which the signal is mostly driven by BIN1, PICALM ABCA7 and CLU. The second cluster contained 21 variants and included genes that have also been related to other dementia types (e.g., GRN, TMEM107B, SNX1, MAPT, CTSB and CTSH).