AXL mediated partially the regulatory effects of NR1D2 on PI3K/AKT axis and promoted proliferation, migration, and invasion of glioblastoma cells. Besides, Rev‐erbβ knockdown remarkably impaired the maturation of focal adhesion and assembly of F‐actin, along with downregulated phospho‐FAK, and proteins involved in actin nucleation and polymerization (phospho‐RAC1/CDC42, WAVE and PFN2). The gene discussed is NR1D2; the disease is glioblastoma.