LPS reduced serum iron and transferrin saturation in hyperferremic wild type mice on HID and Hjv-/- mice on control diet or IDD, but not below the baseline of wild type mice on control diet, the only animals that developed a robust hypoferremic response (Figure 2A–B); see also ratios of serum iron levels between untreated and LPS-treated mice in Figure 2A. Here, TF is linked to intervertebral disk degenerative disorder.