Thus, Hjv-/- mice, a model of juvenile hemochromatosis characterized by severe iron overload and hepcidin deficiency (Huang et al., 2005), exhibit blunted inflammatory induction of hepcidin and fail to mount a hypoferremic response following LPS treatment or infection with E. coli (Fillebeen et al., 2018). Here, HAMP is linked to hemochromatosis.