Overall, the enzyme activity of LAL in control, Wolman disease, and CESD were 123.9 ± 53.9 μmol/h/L (n = 131), 6.6 ± 0.9 μmol/h/L (n = 3), and 4.8 ± 0.3 μmol/h/L (n = 3) (Mean ± SD), respectively (Fig. 3A). Here, LIPA is linked to cholesteryl ester storage disease.