ALK and non-small cell lung carcinoma: In the 28 patients with ALK+ NSCLC who received the recommended brigatinib dosing regimen (180 mg once daily with 7-d lead-in at 90 mg), the confirmed ORR was 79% (95% CI: 59–92), with median duration of response of 14.8 months (95% CI: 7.9–33.3).