AKT1 and obesity due to melanocortin 4 receptor deficiency: These miRNAs were suspected to target the molecules including STAT3, PI3K, AKT and FOXO1 in leptin signal in obesity, PPARγ and FOXO1 in adipogenesis pathway, and p38MAPK, PPARγ and PPARα in white adipose tissue browning pathway (Fig. 3, Fig. 4, Fig. 5).