These canonical pathways include leptin signal in obesity (10 molecules in our dataset/76 molecules in the pathway [ratio: 0.132]; pathway p value = 1.79E-05 [Fig. 3]), adipogenesis pathway (16 molecules in our dataset/135 molecules in the pathway [ratio: 0.119]; pathway p value = 2.52E-07 [Fig. 4]), and white adipose tissue browning pathway (12 molecules in our dataset/138 molecules in the pathway [ratio: 0.087]; pathway p value = 1.73E-04 [Fig. 5]). Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.