12 necroptosis-related lncRNAs highly associated with OS in glioma patients were identified by lasso and univariate and multifactorial Cox regression, and risk prognostic models were constructed by risk score (i.e., AC025857.2, AC092718.4, AL513534.1, AC083864.2, ZNF236-DT, AC099850.3, AL590094.1, AC010226.1, POLR2J4, AC023024.1, SLC25A21-AS1, and AC109439.2). This evidence concerns the gene SLC25A21 and glioma.