A recent study conducted by Wang and his colleagues discovered that miRNA-124 binds to circHIPK3 and modulates the proinflammatory mediators, such as interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-12 (IL-12), and tumor necrosis factor-alpha (TNF-α), and that intrathecal administration of circHIPK3 shRNA can be applied in the treatment of NP in rats with diabetes [6]. Here, TNF is linked to diabetes mellitus.