Advillin is implicated in somatosensory neuronal subtype-specific axonal regeneration and NP, and it has been demonstrated to be substantially linked to newborn focal adhesion proteins [15] ITGB4, which belongs to the integrin gene family, is implicated in the migration of tumor cells and has been shown to be a good prognostic indicator in patients with colon cancer [16]. This evidence concerns the gene ITGB4 and malignant colon neoplasm.