Also, patients with colon cancer had higher percentages of activated T cells CD4 memory, T cells follicular helper, macrophages M0 and M1, resting/activated dendritic cells, and neutrophils, and lower percentages of B cells naïve, plasma cells, T cells CD4 memory resting, activated NK cells, monocytes, macrophages M2, and activated mast cells compared with healthy controls (p < 0.01; Figure S1). Here, CD4 is linked to malignant colon neoplasm.