A prognostic risk assessment model was constructed for colon cancer using the expression signature of six immune-related DEGs, including CXCL1 (upregulated), EREG (upregulated), CCL24 (eotaxin-2; upregulated), FABP4 (downregulated), TPM2 (downregulated), and SEMA3G (downregulated). This evidence concerns the gene EREG and colonic neoplasm.