In conclusion, this study found that psoralen has a good antiglioma pharmacological effect in vitro. These effects may be profoundly achieved by inhibiting the expression of JAK2, PIK3CA, PIK3CB, and PIK3CG genes and JAK2 and PI3K proteins, inhibiting the proliferation of cancer cells and promoting the apoptosis and migration of cancer cells. Here, PIK3CG is linked to cancer.